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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
E2F1
All Species:
24.55
Human Site:
Y245
Identified Species:
45
UniProt:
Q01094
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q01094
NP_005216.1
437
46920
Y245
T
D
S
Q
R
L
A
Y
V
T
C
Q
D
L
R
Chimpanzee
Pan troglodytes
XP_524538
437
47536
Y249
K
A
N
K
R
L
A
Y
V
T
Y
Q
D
I
R
Rhesus Macaque
Macaca mulatta
XP_001103717
502
53768
Y310
T
D
S
Q
R
L
A
Y
V
T
C
Q
D
L
R
Dog
Lupus familis
XP_542963
571
61192
Y380
S
D
S
Q
R
L
A
Y
V
T
C
Q
D
L
R
Cat
Felis silvestris
Mouse
Mus musculus
Q61501
430
46305
Y240
S
D
T
Q
R
L
A
Y
V
T
C
Q
D
L
R
Rat
Rattus norvegicus
Q62814
300
33206
D119
S
I
K
N
V
M
E
D
S
I
N
N
R
F
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515449
468
50133
Q257
D
S
T
A
V
R
Q
Q
Q
A
L
R
R
D
L
Chicken
Gallus gallus
Q90977
403
43534
Y222
P
S
N
Q
H
A
A
Y
V
T
C
Q
D
L
R
Frog
Xenopus laevis
NP_001090608
426
47125
V237
E
S
H
D
Y
G
Y
V
T
C
Q
D
L
R
S
Zebra Danio
Brachydanio rerio
NP_001074097
429
46452
S248
Q
M
T
E
E
I
H
S
Q
K
Y
A
Y
V
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27368
805
87442
Y372
E
N
S
G
G
M
A
Y
V
T
Q
N
D
L
L
Honey Bee
Apis mellifera
XP_396223
416
46049
K235
R
L
I
H
G
A
D
K
N
L
R
E
L
C
A
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001123287
404
44387
N222
V
N
L
H
S
E
L
N
D
L
E
A
Q
E
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.7
86
70.9
N.A.
84.6
23.1
N.A.
39.9
59.9
49.8
37.2
N.A.
20.6
29.7
N.A.
38.4
Protein Similarity:
100
54.4
86.2
72.6
N.A.
88.5
37.9
N.A.
51.2
70
63.3
53.7
N.A.
31.5
46.4
N.A.
54.2
P-Site Identity:
100
60
100
93.3
N.A.
86.6
0
N.A.
0
66.6
0
0
N.A.
46.6
0
N.A.
0
P-Site Similarity:
100
80
100
100
N.A.
100
13.3
N.A.
13.3
73.3
0
26.6
N.A.
60
6.6
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
8
0
16
54
0
0
8
0
16
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
8
39
0
0
8
0
% C
% Asp:
8
31
0
8
0
0
8
8
8
0
0
8
54
8
0
% D
% Glu:
16
0
0
8
8
8
8
0
0
0
8
8
0
8
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% F
% Gly:
0
0
0
8
16
8
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
8
16
8
0
8
0
0
0
0
0
0
0
0
% H
% Ile:
0
8
8
0
0
8
0
0
0
8
0
0
0
8
0
% I
% Lys:
8
0
8
8
0
0
0
8
0
8
0
0
0
0
8
% K
% Leu:
0
8
8
0
0
39
8
0
0
16
8
0
16
47
16
% L
% Met:
0
8
0
0
0
16
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
16
16
8
0
0
0
8
8
0
8
16
0
0
0
% N
% Pro:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
8
0
0
39
0
0
8
8
16
0
16
47
8
0
0
% Q
% Arg:
8
0
0
0
39
8
0
0
0
0
8
8
16
8
47
% R
% Ser:
24
24
31
0
8
0
0
8
8
0
0
0
0
0
16
% S
% Thr:
16
0
24
0
0
0
0
0
8
54
0
0
0
0
8
% T
% Val:
8
0
0
0
16
0
0
8
54
0
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
8
54
0
0
16
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _